In this penultimate episode of the video series that I recorded with ExchangeCME, I connect with Dr. Benjamin Scirica to explore the complex intersection of obesity and cardiovascular disease, with a focus on heart failure with preserved ejection fraction (HFpEF). Together, we examine the diagnostic challenges unique to patients with obesity, discuss the pathophysiologic drivers linking excess adiposity to cardiometabolic dysfunction, and review how glucagon-like peptide-1 (G